A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution

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Houghton Mifflin Harcourt #ad - That is, until 2015, when biologist jennifer doudna called for a worldwide moratorium on the use of the gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, simplest, and some cancers.

Finalist for the los angeles times book prize    “The future is in our hands as never before, and this book explains the stakes like no other. George lucas“Required reading for every concerned citizen. New york review of books   not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use.

A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution #ad - Writing with fellow researcher sam Sternberg, Doudna shares the thrilling story of her discovery and describes the enormous responsibility that comes with the power to rewrite the code of life. Yet even the tiniest changes to dna could have myriad, unforeseeable consequences—to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans.

An invaluable account. We owe Doudna several times over. Guardian.

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Virolution

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William Collins #ad - His explanation of the role of natural selection in driving the evolution of life on earth depended on steady variation of living things over time – but he was unable to explain how this variation occurred. Not only was the human genome unbelievably simple it is only ten times more complicated than a bacteria, but embedded in the code were large fragments that were derived from viruses – fragments that were vital to evolution of all organisms and the evidence for a fourth and vital source of variation – viruses.

Virolution is the product of dr frank ryan's decade of research at the frontiers of this new science – now called viral symbiosis – and the amazing revolution that it has had in these few years. In the 150 years since publication of the Origin of Species, we have discovered three main sources for this variation – mutation, hybridisation and epigenetics.

The extraordinary role of viruses in evolution and how this is revolutionising biology and medicine. Darwin's theory of evolution is still the greatest breakthrough in biological science. As scientists begin to look for evidence of viral involvement in more and more processes, they have discovered that they are vital in nearly every case.

Virolution #ad - Then on sunday, 12th february, 2001 the evidence for perhaps the most extraordinary cause of variation was simultaneously released by two organisations – the code for the entire human genome. And with this understanding comes the possibility of manipulating the role of the viruses to help fight a huge range of diseases.

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The Epigenetics Revolution: How Modern Biology Is Rewriting Our Understanding of Genetics, Disease, and Inheritance

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Columbia University Press #ad - Surveying the twenty-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics. Nessa carey, a leading epigenetics researcher, connects the field's arguments to such diverse phenomena as how ants and queen bees control their colonies; why tortoiseshell cats are always female; why some plants need cold weather before they can flower; and how our bodies age and develop disease.

Reaching beyond biology, the long-term effects of famine, epigenetics now informs work on drug addiction, and the physical and psychological consequences of childhood trauma. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity.

The Epigenetics Revolution: How Modern Biology Is Rewriting Our Understanding of Genetics, Disease, and Inheritance #ad - . Carey concludes with a discussion of the future directions for this research and its ability to improve human health and well-being. Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth.

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I Contain Multitudes: The Microbes Within Us and a Grander View of Life

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Ecco #ad - It will change both our view of nature and our sense of where we belong in it. Ed yong, prompts us to look at ourselves and our animal companions in a new light—less as individuals and more as the interconnected, whose humor is as evident as his erudition, interdependent multitudes we assuredly are. The microbes in our bodies are part of our immune systems and protect us from disease.

Joining the ranks of popular science classics like the botany of desire and The Selfish Gene, and vastly entertaining examination of the most significant revolution in biology since Darwin—a “microbe’s-eye view” of the world that reveals a marvelous, wondrously informative, a groundbreaking, radically reconceived picture of life on earth.

I Contain Multitudes: The Microbes Within Us and a Grander View of Life #ad - Every animal, whether human, squid, or wasp, is home to millions of bacteria and other microbes. Bacteria provide squid with invisibility cloaks, help beetles to bring down forests, and allow worms to cause diseases that afflict millions of people. Many people think of microbes as germs to be eradicated, but those that live with us—the microbiome—build our bodies, protect our health, shape our identities, and grant us incredible abilities.

In this astonishing book, ed yong takes us on a grand tour through our microbial partners, and introduces us to the scientists on the front lines of discovery. In the deep oceans, mysterious creatures without mouths or guts depend on microbes for all their energy.

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Modern Prometheus: Editing the Human Genome with Crispr-Cas9

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Cambridge University Press #ad - Kozubek weaves together the fascinating stories of many of the scientists involved in the development of gene editing technology. Tracing events across a fifty-year period, this is the story of gene editing - the science, from the first gene splicing techniques to the present day, the impact and the potential.

Would you change your genes if you could? as we confront the 'industrial revolution of the genome', for the first time, the recent discoveries of Crispr-Cas9 technologies are offering, cheap and effective methods for editing the human genome. Along the way, he demystifies how the technology really works and provides vivid and thought-provoking reflections on the continuing ethical debate.

Modern Prometheus: Editing the Human Genome with Crispr-Cas9 #ad - Ultimately, kozubek places the debate in its historical and scientific context to consider both what drives scientific discovery and the implications of the 'commodification' of life. This opens up startling new opportunities as well as significant ethical uncertainty.

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Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves

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Basic Books #ad - Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.

In regenesis, george church and science writer Ed Regis explore the possibilities of the emerging field of synthetic biology. These technologies-far from the out-of-control nightmare depicted in science fiction-have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span.

Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves #ad - A harvard biologist and master inventor explores how new biotechnologies will enable us to bring species back from the dead, unlock vast supplies of renewable energy, and extend human life.

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The Gene: An Intimate History

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Scribner #ad - The gene is a book we all should read” USA TODAY. Siddhartha mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010 . The #1 new york times bestseller a new york times notable book a washington post and seattle times best book of the Year From the Pulitzer Prize–winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” Elle.

Dr. A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” Milwaukee Journal-Sentinel, The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master.

In riveting and dramatic prose, watson and franklin, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, all the way through the revolutionary twenty-first century innovators who mapped the human genome. Mukherjee expresses abstract intellectual ideas through emotional stories…and swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” The Washington Post.

The Gene: An Intimate History #ad - In this biography mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, fates, personalities, identities, and choices. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” The New York Times.

Throughout, the story of mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world.

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The Tangled Tree: A Radical New History of Life

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Simon & Schuster #ad - He is simply astonishing, humor, guts, one of that rare class of writer gifted with verve, ingenuity, and great heart” Elle. Now, in the tangled tree, he explains how molecular studies of evolution have brought startling recognitions about the tangled tree of life—including where we humans fit upon it.

In the mid-1970s, scientists began using DNA sequences to reexamine the history of all life. It turns out that HGT has been widespread and important. For instance, we now know that roughly eight percent of the human genome arrived not through traditional inheritance from directly ancestral forms, but sideways by viral infection—a type of HGT.

The tangled tree is a brilliant guide to our transformed understanding of evolution, of life’s history, and of our own human nature. In the tangled tree david quammen, “one of that rare breed of science journalists who blends exploration with a talent for synthesis and storytelling” Nature, chronicles these discoveries through the lives of the researchers who made them—such as Carl Woese, the notorious maverick whose wild ideas about “mosaic” creatures proved to be true; and Tsutomu Wantanabe, the most important little-known biologist of the twentieth century; Lynn Margulis, who discovered that the scourge of antibiotic-resistant bacteria is a direct result of horizontal gene transfer, bringing the deep study of genome histories to bear on a global crisis in public health.

The Tangled Tree: A Radical New History of Life #ad - Thanks to new technologies such as crISPR, we now have the ability to alter even our genetic composition—through sideways insertions, as nature has long been doing. Longlisted for the national book award for nonfiction and a new york times Notable Book of 2018 Nonpareil science writer David Quammen explains how recent discoveries in molecular biology can change our understanding of evolution and life’s history, with powerful implications for human health and even our own human nature.

Quammen is no ordinary writer.

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The Double Helix: A Personal Account of the Discovery of the Structure of DNA

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Scribner #ad - At the time, watson was only twenty-four, a young scientist hungry to make his mark. With humility unspoiled by false modesty, watson relates his and Crick’s desperate efforts to beat Linus Pauling to the Holy Grail of life sciences, the identification of the basic building block of life. Never has a scientist been so truthful in capturing in words the flavor of his work.

The classic personal account of watson and Crick’s groundbreaking discovery of the structure of DNA, now with an introduction by Sylvia Nasar, author of A Beautiful Mind. By identifying the structure of dnA, the molecule of life, Francis Crick and James Watson revolutionized biochemistry and won themselves a Nobel Prize.

The Double Helix: A Personal Account of the Discovery of the Structure of DNA #ad - . His uncompromisingly honest account of the heady days of their thrilling sprint against other world-class researchers to solve one of science’s greatest mysteries gives a dazzlingly clear picture of a world of brilliant scientists with great gifts, very human ambitions, and bitter rivalries.

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Genius: The Life and Science of Richard Feynman

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Open Road Media #ad - Robert oppenheimer, where the giddy young man held his own among the nation’s greatest minds. And he was just getting started. In this sweeping biography, james gleick captures the forceful personality of a great man, integrating Feynman’s work and life in a way that is accessible to laymen and fascinating for the scientists who follow in his footsteps.

New york times bestseller: this life story of the quirky physicist is “a thorough and masterful portrait of one of the great minds of the century” The New York Review of Books. Raised in depression-era rockaway beach, eccentric, physicist Richard Feynman was irreverent, and childishly enthusiastic—a new kind of scientist in a field that was in its infancy.

Genius: The Life and Science of Richard Feynman #ad - There, culminating in the trinity test, on July 16, 1945, Feynman turned theory into practice, when the Atomic Age was born. He was only twenty-seven. His quick mastery of quantum mechanics earned him a place at Los Alamos working on the Manhattan Project under J.

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North Pole, South Pole: The Epic Quest to Solve the Great Mystery of Earth's Magnetism

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The Experiment #ad - Turner has a great story to tell, and she tells it well. The press New Zealand. In recent years, many very good books for interested non-scientists have been published: Richard Dawkins’s Climbing Mount Improbable and The Ancestor’s Tale, and Dava Sobel’s Longitude and The Planets, Stephen Jay Gould’s The Lying Stones of Marrakech, to name some of them.

Over two thousand years after the invention of the compass, Einstein called the source of Earth’s magnetic field one of greatest unsolved mysteries of physics. Is a worthy addition to that list .  .  . Here, for the first time, is the complete history of the quest to understand the planet’s attractive pull—from the ancient Greeks’ fascination with lodestone to the geological discovery that the North Pole has not always been in the North—and to the astonishing modern conclusions that finally revealed the true source.

North Pole, South Pole: The Epic Quest to Solve the Great Mystery of Earth's Magnetism #ad - North pole, South Pole .  .  . Why do compass needles point north—but not quite north? what guides the migration of birds, the world’s great scientists have grappled with these questions, and fish across the world’s oceans? How is Earth able to sustain life under an onslaught of solar wind and cosmic radiation? For centuries, whales, all rooted in the same phenomenon: Earth’s magnetism.

Richly illustrated and skillfully told, south Pole unfolds the human story behind the science: that of the inquisitive, persevering, North Pole, and often dissenting thinkers who unlocked the secrets at our planet’s core. This “fantastic story” of one of physics’ great riddles takes us through centuries of scientific history Simon Lamb, author of Devil in the Mountain.

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